Following the call at the AIDS High Level Meeting in New York for more effective HIV prevention amongst injecting drug users, a group of NGOs initiated a sign on letter to senior UN officials pointing out the contradictions between the drive to tackle this problem, and the stigmatisation and marginalisation of drug users that is often part of UN-supported drug control activities. The letter, that is released to coincide with the International Day Against Drug Abuse and Illicit Trafficking, calls for greater cohesion between these two areas of UN activity.