The CDPE strives to improve community health and safety by conducting research and outreach on best practices in drug policy. We work collaboratively with governments, affected communities, and civil society to guide effective and evidence-based policy responses to substance use. The CDPE was founded as the International Centre for Science in Drug Policy (ICSDP) in 2010 at the BC Centre for Excellence in HIV/AIDS in Vancouver, Canada. The CDPE is now housed within the Li Ka Shing Knowledge Institute at St. Michael’s Hospital in Toronto, Canada. The CDPE endeavors to be a primary source for rigorous scientific evidence on the impacts of illegal drug policy on community health and safety. To that end, the CDPE produces research products that adhere to the highest standards of peer-reviewed scientific research. The CDPE also conducts outreach and knowledge translation to inform policymakers, affected communities, key stakeholders, and the general public on pressing current issues surrounding illegal drugs and drug policy. The CDPE also leads innovative primary research, including on drug checking services, supervised injection services, injection drug use prevention, overdose response, and drug policy evaluation.