The Middle East and North Africa Harm Reduction Association (MENAHRA) is a regional network on Harm Reduction covering 20 countries in the Middle East and North Africa (MENA) region. MENAHRA’s mission is to prolong and improve the quality of life of injecting drug users in the region. It seeks to promote humane, tolerant policy and practice for people who use drugs, with particular respect to their health, human rights and freedoms. Through its activities, MENAHRA seeks to empower this marginalized population, and to promote increased government effectiveness with relation to the HIV response in the region. Recognizing the crucial role of the civil society in delivering health services to key populations at increased risk, MENAHRA’s key strategy is strengthening the role of the civil society in implementing harm reduction in the MENA region.