This Summit will bring together experts from around the world to discuss the legal, cultural, and political issues around the emerging psychedelic renaissance. Efforts to decriminalize or legalize psychedelics have picked up steam around the United States, with Denver recently decriminalizing psilocybin mushrooms and Oakland decriminalizing all natural psychedelics. In addition, advocates in Oregon are planning a statewide ballot initiative to regulate psilocybin in 2020. The topics addressed will include: the process of applying for religious exemptions with the DEA; psilocybin decriminalization initiatives; the right to ameliorate pain and suffering; cognitive liberty; drug use and human rights; ibogaine bills; the upcoming FDA regulation of MDMA and psilocybin; psychedelic harm reduction; licensed health care providers and psychedelic-assisted therapy; the paradoxes of cannabis regulation and NIDA monopoly for research cannabis; conservation of endangered species; human’s relationship to sacred plants and nature; the continuities and discontinuities between recreational, therapeutic and religious use of drugs; the future legal markets; and the commercialization of psychedelics. The Summit aims to discuss the future of psychedelic practices in the US, including decriminalization, legalization, and medicalization. Finally, Chacruna will officially launch the Council for the Protection of Sacred Plants at the Summit. The Council is an initiative of the Chacruna Institute that advocates for the legality of sacred plant medicines among indigenous peoples and non-indigenous communities, encourages legal harm-reduction practices that protect those who use them, educates about conservation of plant species, documents relevant legal and social issues, and consults on legal cases.