This year’s Results Report shows clearly why we must step up the fight against the epidemics of HIV, TB and malaria. While the Global Fund partnership continues to have huge impact, saving 32 million lives since 2002, the world is not on track to meet the Sustainable Development Goal 3 (SDG 3) target of ending the epidemics by 2030. We need a sharp change of trajectory.

In the fight against HIV, we continue to make progress through expanding testing and treatment towards UNAIDS’s 90-90-90 targets. To maximize impact, we must improve retention and viral suppression rates and the treatment of coinfections through greater focus on the quality of treatment services, including more differentiated approaches to reflect the distinct needs of different communities, greater integration of services and swifter adoption of new regimens.

Yet, while effective diagnosis and treatment are fundamental to the strategy to defeat HIV, it is increasingly clear that we must get better at prevention and in particular, in addressing the underlying drivers of new infections. We will only beat HIV if we dismantle the human rights barriers faced by key populations that simultaneously increase their vulnerability to infection and impair their access to health services. Likewise, we will only beat HIV if we tackle the stark structural gender inequalities that make adolescent girls and young women in sub-Saharan Africa twice as likely to be infected with HIV than their male peers.

The United Nations High-Level Meeting on Tuberculosis in September 2018 represented a significant milestone in the fight against the infectious disease that is now responsible for more deaths than any other: for the first time, political leaders across the world acknowledged the scale of the epidemic, recognized the pace of progress is unacceptable and committed to a bold new goal of finding, and treating, 40 million people from 2018-2022.